CV

Sungpil Han

CV PDF

EDUCATION

M.D. 2007 - 2015
School of Medicine, Pusan National University Pusan, Korea

Ph.D., Molecular Cell Biology and Genetics 2009 - 2013
School of Medicine, Pusan National University Pusan, Korea

B.S., Electrical Engineering 2000 - 2007
College of Engineering, Korea University Seoul, Korea

CLINICAL EXPERIENCES

Resident in Clinical Pharmacology and Therapeutics Mar 2016 - Present
Asan Medical Center, University of Ulsan Seoul, Korea

Intern Mar 2015 - Feb 2016
Asan Medical Center, University of Ulsan Seoul, Korea

Clinical and Research Elective in Neuropathology Feb 2009 - Apr 2009
School of Medicine, Johns Hopkins University Baltimore, MD

Clinical Elective in Neurosurgery and Pathology Aug.2008
School of Medicine, Kyushu University Fukuoka, Japan

CLINICAL TRIALS INVOLVED

Duration Role Study Therapeutic area/Phase
Jul 2017 - Sub-I SIT CPT/Phase I (Dermal fibrosis treatment drug)
Mar 2017 - Sub-I SIT CPT/Phase I (GH deficiency treatment drug)
Feb 2017 - Sub-I SIT CPT/Phase I (Osteoporosis treatment drug)
Feb 2017 - Sub-I IIT CPT/Retrospective (Vancomycin TDM)
Jan 2017 - Sub-I SIT CPT/Phase I (BPH treatment drug)
Aug 2016 - Sub-I SIT CPT/Phase I (Tuberculosis treatment drug)
Apr 2016 - Sub-I SIT CPT/Phase I (BPH treatment drug)
Mar 2016 - Sub-I SIT CPT/Phase I (Endometriosis treatment drug)
Mar 2016 - Sub-I SIT CPT/Phase I (Osteoporosis treatment drug)
Mar 2016 - Sub-I SIT CPT/Phase I (Anti-platelet agent)
Mar 2010 - Dec 2012 Researcher IIT NR/Phase I (Zinbryta, MS treatment mAb)

RESEARCH EXPERIENCES

Sub-Investigator Mar 2016 - Present
Asan Medical Center, University of Ulsan Seoul, Korea

Predoctoral Fellow Jan 2010 - Dec 2012
Neuroimmunology branch, NINDS, National Institutes of Health Bethesda, MD

Research Assistant Jan 2009 - Dec 2009
Pusan National University, School of Medicine Pusan, Korea

PUBLICATIONS

Link to Google Scholar

Kim, H, S. Han, Y. Cho, S. Yoon and K. Bae (2018). “Development of R packages: NonCompart' andncar’ for noncompartmental analysis (NCA)”. In: Translational and Clinical Pharmacology 26.1, p. 10. DOI: 10.12793/tcp.2018.26.1.10. URL: https://doi.org/10.12793/tcp.2018.26.1.10.

Waters, R. S, J. S. A. Perry, S. Han, B. Bielekova and T. Gedeon (2018). “The effects of interleukin-2 on immune response regulation”. Eng. In: Mathematical medicine and biology : a journal of the IMA 35.1, pp. 79-119. ISSN: 1477-8602. DOI: 10.1093/imammb/dqw021. PMID: 28339682.

Han, S, Y. Cho, S. Yoon, H. Kim and K. Bae (2017). “Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications”. In: Translational and Clinical Pharmacology 25.3, p. 141. DOI: 10.12793/tcp.2017.25.3.141. URL: https://doi.org/10.12793/tcp.2017.25.3.141.

Han, S, Y. C. Lin, T. Wu, A. D. Salgado, I. Mexhitaj, S. C. Wuest, E. Romm, J. Ohayon, R. Goldbach-Mansky, A. Vanderver, A. Marques, C. Toro, P. Williamson, I. Cortese and B. Bielekova (2014). “Comprehensive immunophenotyping of cerebrospinal fluid cells in patients with neuroimmunological diseases”. Eng. In: Journal of immunology (Baltimore, Md. : 1950) 192.6, pp. 2551-63. ISSN: 1550-6606. DOI: 10.4049/jimmunol.1302884. PMID: 24510966.

Perry, J. S. A, S. Han, Q. Xu, M. L. Herman, L. B. Kennedy, G. Csako and B. Bielekova (2012). “Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis”. Eng. In: Science translational medicine 4.145, p. 145ra106. ISSN: 1946-6242. DOI: 10.1126/scitranslmed.3004140. PMID: 22855463.

Han, S, J. Kim, M. Han, H. Sim, K. Kim, S. Yoon, S. Baek, B. Kim and S. Oh (2011). “SNAI1 is involved in the proliferation and migration of glioblastoma cells”. Eng. In: Cellular and molecular neurobiology 31.3, pp. 489-96. ISSN: 1573-6830. DOI: 10.1007/s10571-010-9643-4. PMID: 21225336.

Wuest, S. C, J. H. Edwan, J. F. Martin, S. Han, J. S. A. Perry, C. M. Cartagena, E. Matsuura, D. Maric, T. A. Waldmann and B. Bielekova (2011). “A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy”. Eng. In: Nature medicine 17.5, pp. 604-9. ISSN: 1546-170X. DOI: 10.1038/nm.2365. PMID: 21532597.

PUBLISHED PROCEEDINGS

Han, S, Y. Kim, H. Y. Choi, D. Soh, J. Kim, J. Nam, J. Kim, K. Bae and H. Lim (2017). “Safety, Tolerability, and Pharmacokinetics of Single and Multiple Dose JPI-289, A Novel Poly (ADP-Ribose) Polymerase-1 Inhibitor in First-In-Human Study of Healthy Volunteers”. In: Clinical Therapeutics 39.8, p. e48. DOI: 10.1016/j.clinthera.2017.05.148.

Han, S, H. Y. Choi, Y. H. Kim, W. J. Kim, K. Bae and H. Lim (2017). “Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of CTB-001, Recently Developed Bivalirudin”. In: Clinical Therapeutics 39.8, p. e54. DOI: 10.1016/j.clinthera.2017.05.169.

Han, S, H. Y. Choi, Y. H. Kim, J. Y. Nam, G. S. Song, H. Lim and K. Bae (2017). “Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Single and Multiple Oral Doses of CJ-12420 (Tegoprazan), A Novel Potassium-Competitive Acid Blocker (P-CAB) in Healthy Male Subjects”. In: Clinical Therapeutics 39.8, pp. e97-e98. DOI: 10.1016/j.clinthera.2017.05.306.

Han, S, K. Lim, S. Cho, J. Kim, S. Choe, J. Jung, J. Ghim, H. Jeong, T. Yoo, S. Kim and others (2016). “Effects of single oral administration of SKI2670, gonadotropin-releasing hormone (GnRH) antagonist, in healthy pre-menopausal women”. In: Fertility and Sterility 106.3, p. e273. DOI: 10.1016/j.fertnstert.2016.07.785.

Han, S, A. D. Salgado, E. Romm and B. Bielekova (2012). “Comprehensive monitoring of intrathecal immune cells in patients with multiple sclerosis by 12-color flow cytometric immunophenotyping”. In: Journal of Neuroimmunology 253.1-2, pp. 98-98. DOI: 10.1016/j.jneuroim.2012.10.001.

Han, S, J. S. Perry, Q. Xu, L. B. Kennedy and B. Bielekova (2012). “Inhibitory effects of CD25 blockade on development of pro-inflammatory innate lymphoid cells is associated with decreased intrathecal inflammation in MS”. In: Journal of Neuroimmunology 253.1-2, pp. 67-67. DOI: 10.1016/j.jneuroim.2012.10.001.

Han, S, A. Salgado, T. Alfahad and B. Bielekova (2012). “Flow Cytometric Immunophenotyping of the Blood and CSF of Patients with Multiple Sclerosis”. In: Neurology 78.1 Supplement, pp. P02-081.

Wuest, S, S. Han, J. Martin, D. Maric and B. Bielekova (2011). “Daclizumab Inhibits Expansion of Antigen (Ag)-Specific T Cells by Blocking IL-2 Transpresentation by Dendritic Cells”. In: Neurology 76.9, pp. A240-A240.

Han, S, I. Cortese and B. Bielekova “Effects of Long-Term (> 5 Years) Daclizumab Therapy on Lymphocyte Subpopulations - Comparison of Immediate Ex-Vivo Immunophenotyping with Commercially-Available Assay”. English. In: NEUROLOGY 76.9, 4. 63rd AAN Annual Meeting, Honolulu, HI, APR 09-16, 2011, pp. A239-A240. ISSN: 0028-3878.

Perry, J, S. Han, L. B. Kennedy and B. Bielekova “Opposing regulation between lymphoid tissue inducer cells and immunoregulatory CD56bright NK cells underlies therapeutic benefit of daclizumab in MS”. English. In: JOURNAL OF NEUROIMMUNOLOGY 228.1-2, SI. 10th Congress of the International-Society-of-Neuroimmunology (ISNI), Sitges, SPAIN, OCT 26-30, 2010, pp. 111-112. ISSN: 0165-5728. DOI: 10.1016/j.jneuroim.2010.08.001.

OTHER PROCEEDINGS

Sungpil Han (2018), TBD, PAGE 2018, Switzerland

Sungpil Han (2016), First-in-human Study Assessing Safety, Tolerability, and Pharmacokinetics of JPI-289, a Novel Poly (ADP-ribose) Polymerase-1 (PARP-1) Inhibitor in Healthy Male Volunteers, Korean Society of Clinical Pharmacology and Therapeutics Fall Symposium, 2016, Jeonju, Korea

Simone Wuest, SungPil Han, Jayne Martin, Dragan Maric, Bibiana Bielekova (2011) “Anti-CD25 Antibody Inhibits Antigen-specific T cell Expansion by Blocking IL-2 Transpresentation by Dendritic Cells”, Federation of Clinical Immunology Societies 2011, Washington DC

Justin Perry, SungPil Han, Lucy Kennedy, Bibiana Bielekova (2011) “Opposing Developmental Regulation Between Lymphoid Tissue Inducer Cells and Immunoregulatory CD56bright NK Cells Contributes to Therapeutic Benefit of Daclizumab in Multiple Sclerosis”, Federation of Clinical Immunology Societies 2011, Washington DC

SungPil Han, Justin Perry, Kory Johnson, Bibiana Bielekova (2011) “Signaling Though High- versus Intermediate-affinity Interleukin-2 (IL-2) Receptor Provides Qualitatively Different Signals to T cells”, Annual conference of National Institute of Neurological Disorders and Stroke 2011, VA

Simone Wuest, Jayne Martin, SungPil Han, Justin Perry, Thomas Waldmann, Bibiana Bielekova (2011) “Important role for IL-2 transpresentation in the induction of antigen-specific T cell responses by dendritic cells.”, Keystone Symposia on Molecular and Cellular Biology: Dendritic cells and the initiation of adaptive immunity. Santa Fe, NM

SungPil Han, Bibiana Bielekova (2010) “Comprehensive investigation of the mechanism of action of CD25-blocking Ab DAC-HYP in multiple sclerosis”, Annual Bioscience and Engineering Symposium 2010, Bethesda, MD

ACADEMIC PRESENTATIONS

The 13th Congress of EACPT Prague, Czech | Jun 2017
Young Clinical Pharmacologists Session: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Dose JPI-289, a Novel Poly (ADP-ribose) Polymerase-1 Inhibitor in First-in-human Study of Healthy Volunteers

Expert Meeting, KFDA Seoul, Korea | Apr 2017
ICH E18: Guideline on Genomic Sampling and Management of Genomic Data

EDISON Conference 2017 Daejeon, Korea | Mar 2017
Monte Carlo Simulation of Plasma Caffeine Concentration by Using Population Pharmacokinetic Model

Korean Society of Clinical Pharmacology and Therapeutics Symposium Jeonju, Korea | Oct 2016
Effects of Single Oral Administration of SKI2670, Gonadotropin-releasing Hormone (GnRH) Antagonist: A Randomized, Double-blind, Placebo-controlled, First-in-human Study in Healthy Pre-menopausal Women

NIH Neuroimmunology Branch Seminar Bethesda, MD | 2012
Comprehensive Investigation of Mechanism of Action of DAC HYP in Patients with Multiple Sclerosis

Annual Bioscience and Engineering Symposium Vienna, VA | Nov 2011
Neuroimmunological findings from patients with multiple sclerosis by flow cytometric immunophenotyping of cerebrospinal fluid and blood

NIH Neuroimmunology Branch Seminar Bethesda, MD | Jun 2011
Immunological findings from DAC HYP Clinical Trial (10-N-0125): Comprehensive ex vivo investigation of DAC HYP in MS patients

PNU Research Festival Gyeongju, Korea | Dec 2009
Genome-wide identification of Gli3 direct target genes during neurodevelopment

STATISTICAL SOFTWARES

Han, S. (2018a). caffsim: Simulation of Plasma Caffeine Concentrations by Using Population Pharmacokinetic Model. R package version 0.2.4.9000. URL: https://github.com/asancpt/caffsim.

Han, S. (2018b). crftools: CRF tools for Asan CPT. R package version 0.2.0. URL: https://github.com/asancpt/crftools.

Han, S. (2018c). glasgowcoma: Glasgow Coma Scale Report. R package version 0.0.0.9000.

Han, S. (2018d). puresas: A SAS Script Generator To Convert CSV To XPT and SAS7BDAT files. R package version 0.1.0.

Han, S. (2017) pkrshiny: Noncompartmental Analysis using pkr R package Shiny application. URL: https://asan.shinyapps.io/pkrshiny

Han, S. (2016) vtdm: Vancomycin TDM Shiny application. URL: https://asan.shinyapps.io/vtdm

Han, S. (2016) caff: Monte Carlo Simulation of Caffeine Shiny application. URL: https://asan.shinyapps.io/caff

Han, S. (2016) noncompart: Noncompartmental Analysis using noncompart R package Shiny application. URL: https://asan.shinyapps.io/noncompart

GRANTS AND AWARDS

Research Prize of EDISON Conference 2017 2017
Minister of Ministry of Science, ICT and Future Planning Daejeon, Korea

Outstanding Research Abstract 2016
KSCPT Seoul, Korea

Outstanding Resident of Asan Global Standard 2016
Asan Medical Center Seoul, Korea

Physician-Scientist Training Program Fellowship 2008 - 2015
National Research Foundation, Korea Daejeon, Korea

Intramural Research Fellowship 2010 - 2012
National Institutes of Health Bethesda, MD

Travel Award 2011
Annual Bioscience and Engineering Symposium Bethesda, MD

Hanmi Travel Award 2011
Baltimore/Washington Metropolitan Area Life Science Association (BLSA) Bethesda, MD

Global Internship Fellowship 2010
National Research Foundation, Korea - Brain Korea 21

Graduate Student Fellowship 2007, 2008
National Research Foundation, Korea - Brain Korea 21

Scholarship of Academic Achievement 2007, 2008
Pusan National University

Scholarship for Exchange Student to University of London 2005, 2006
Korea University

Scholarship of Academic Achievement 2001
Korea University

TEACHING EXPERIENCES

Lecturer and Teaching Assistant Spring 2017
College of Medicine, University of Ulsan Seoul, Korea

Lecturer and Mentor 2016, 2017, 2018
College of Medicine, University of Ulsan Seoul, Korea

Lecturer and Mentor Summer 2010, 2011, 2012
NINDS, National Institutes of Health Bethesda, MD

Lecturer and Mentor Spring, Fall 2009 School of Medicine, Pusan National University Pusan, Korea

SCIENTIFIC SOCIETY AND CONSORTIA MEMBERSHIP

Member 2017 - Present
European Association of Clinical Pharmacology and Therapeutics (EACPT)

Member 2016 - Present
Population Approach Group in Korea (PAGK)

Member 2016 - Present
Korean Society of Clinical Pharmacology and Therapeutics (KSCPT)

Member 2016 - Present
The Korean Society for Reproductive Medicine

Member 2011 - Present
Federation of Clinical Immunology Societies (FOCIS)

Member 2010 - Present
American Academy of Neurology (AAN)

Member 2010 - Present
Korean-American Scientists and Engineers Association (KSEA)

REFERENCES

Professor Kyun-Seop Bae, M.D., Ph.D.
Department of Clinical Pharmacology of Therapeutics
School of Medicine, Asan Medical Center, Seoul, University of Ulsan
Tel : +82-2-3010-4645, E-mail : ksbae@amc.seoul.kr

Professor Hyeong-seok Lim, M.D., Ph.D.
Chief of Department of Clinical Pharmacology of Therapeutics
School of Medicine, Asan Medical Center, Seoul, University of Ulsan
Tel : +82-2-3010-4613, E-mail : mdlhs@amc.seoul.kr

Senior Investigator Bibiana Bielekova, M.D.
Chief of Neuroimmunological Diseases Section
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Tel : (240) 669-2724, E-mail : Bibi.Bielekova@nih.gov

Professor Charles G. Eberhart, M.D./Ph.D.
Departments of Pathology, Ophthalmology, and Oncology
School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Tel : (410) 955-3455, E-mail : ceberha@jhmi.edu

Professor Saeock Oh, M.D., Ph.D.
Department of Anatomy
School of Medicine, Pusan National University, Mulgeum-Eup, Beomeo-Ri, Yangsan, South Korea 626770
Tel : +82-51-510-8045, E-mail : hedgehog@pusan.ac.kr

The up-to-date CV is available here.