The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

• Definition
  • Druggable genome - susceptible to pharmacological interaction - involved in pathological mechanisms leading to disease
• Drugs@FDA

• [Centerwatch.com]

• protein kinase inhibitors : type I and II (pho 안됐을때 conformation inhibition안하는 경우)
• GPCR
  • Rhodopsin
  • Secretin
  • Frizzled GPCR

Indication

Antineoplastic Drug Trials

Antidiabetic

Alzheimer - prevention of tau aggregation - exebryl-1, tideglusib (GSK3)

Appetite Regulation

Conclusion

• 555 unique genes encoding drug targets + 475 potentially nobel genome-encoded